Thiolase



Thiolase involves two different thiolases. The 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. Acetoacetyl-CoA thiolase (ACT) is involved in the thiolysis of acetoacetyl-CoA.

For Bacterial Thiolase see Bacterial thiolase

3-ketoacyl-CoA thiolase
2wu9, 2c7y, 2c7z – KCT peroxisomal residues 36-462 – Arabidopsis thaliana

2wua - KCT peroxisomal residues 17-449 (mutant) – sunflower

2iik – hKCT peroximal - human

3goa – KCT – Salmonella typhimurium

1afw, 1pxt – KCT peroxisomal - yeast

2d3t – PfKCT + fatty oxidation complex β subunit – Pseudomonas fragi

1wdk, 1wdl, 1wdm - PfKCT + fatty oxidation complex α subunit

Acetoacetyl-CoA thiolase
1m4s, 1m4t, 1dlu, 1qfl - ZrACT – Zoogloea ramigera

1dm3, 1dlv – ZrACT + CoA

2wku, 2wl6, 1m1t, 1m3k - ZrACT (mutant)

2wkt, 2wkv, 2wl4, 2wl5, 2vtz, 2vu0, 1m3z – ZrACT (mutant) + CoA

1m1o - ZrACT (mutant) + acetoacetyl-CoA

2vu0, 1nl7 - ZrACT + CoA

2vu1, 2vu2, 1ou6 - ZrACT + pantheteine-11-pivalate

2ib7, 2ib8, 2ib9, 2ibu, 2ibw, 2iby, 2f2s – hACT mitochondrial

1wl5 - hACT cytosolic

1wl4 – hACT cytosolic + CoA